‘Sure thing,’ he replies, giving me a hug. ‘I’ll see you tomorrow, then?’ I say, hopefully. I linger as Dan puts his water bottle into his bag and slings it over his shoulder, flicking his blonde hair back into place. These dance practices go far too quickly for my liking: despite the fact that I practice every day except Sundays and Mondays, I never turn down the opportunity to dance with Dan- and that’s not just because I love dancing. Then he spins me, my entire body twisting as he brings me back upright, his firm arms holding me tightly.Īfter what seems like only seconds, the dance is over, we’ve warmed down with some stretches and we’re both packing our bags ready to go.
Languorously, he bends me backwards, so this time my entire back is arching out, with only his hand on my back keeping me from falling, my hair tumbling down as I fling my arms out dramatically above my head so that they nearly touch the ground. From Dan’s expression, this is just another move for him to perform. For me, every time we do it, it sends little shivers of excitement rushing through my body. When our dance instructor, Sarah, suggested it I wondered if I could ever pull it off, but thankfully, we’ve practiced it so much that it doesn’t faze us in the slightest. I catch a glimpse of our position from the mirrors that line all four walls, and secretly smile at just how intimate this move is. Stepping back in time with the music, I lock my leg around his as he leans backwards, so my body is pressed against his. Our chests touch his gorgeously freckled face just centimetres from mine, smiley blue eyes meeting my own brown ones. We set off, our feet mirroring each other as we go through the routine, pausing as he shifts his weight to one side and swerves our bodies to the right. Even though I’ve stood like this with Dan countless times, I still can’t help the feeling of excitement which makes my heart beat faster at being so close to him.
#IT TAKES TWO TO TANGO FREE#
After two hours of solid practice, we’ve decided to do one more run through before calling it a day- and though I’m exhausted, I’m definitely still up for being in his arms again.Īrranging ourselves in the classic position, my hand resting on his shoulder, his on the small of my back, and our free hands meeting, I feel my pulse quicken. In addition, the impact of the dimeric state of HIV-1 viral RNA is discussed with respect to its importance in efficient viral replication and, consequently, the potential development of antiviral strategies designed to disrupt the formation of dimeric RNA.Stretching out, I pull my hair over one shoulder, and smile over at Dan, my dance partner. The viral sequences and proteins involved in the process of RNA dimerization, both for the initial interstrand contact and subsequent steps that result in the condensed, stable conformation of the genomic RNA, are outlined in this review. Multiple steps in the biogenesis of the genomic full-length RNA are involved in achieving this location and dimeric state. The two strands of RNA are intricately entwined within the core of the mature infectious virus as a ribonuclear complex with the viral proteins, including nucleocapsid.
#IT TAKES TWO TO TANGO FULL#
The two RNA molecules are both positive-sense and often identical furthermore, each RNA encodes the full complement of genetic information required for viral replication. Encapsidating two copies of genomic RNA is one of the characteristics of the retrovirus family. Each viral particle of HIV-1, the infectious agent of AIDS, contains two copies of the full-length viral genomic RNA.
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